Medical Diagnosis Using Volatile Organic Compounds Sensors

Volatile organic compounds (VOCs) are important biomarkers in exhaled breath or skin secretion of patients under various medical or pre-medical conditions. As such, VOCs have been explored as alternative biomarkers in the detection of diseases, including asthma, tuberculosis, and lung cancer. In this regard, a rapid, cost-effective, facile, and sample-free strategy is advantageous and critically needed for premedical screening, medical diagnosis, and health monitoring. In this review, we present an overview of the latest progress of using nanomaterial-based chemo-resistive VOC sensors for fast, real-time, and non-invasive diagnosis of diseases via detecting VOCs from exhaled breath and other sources from human body. The origin and emission of VOCs are summarized from human body, and the VOC signatures are discussed as related to specific disease. Targeting specific VOCs, chemoresistive sensors using different nanomaterials are reviewed in terms of their sensing performance metrics including sensitivity, selectivity, response/recovery time, and stability. Various strategies for improving VOC sensor performance are discussed, specifically on the material and signal processing-based approaches. © 2022 World Scientific Publishing Company.