Fabrication of novel biodegradable braided nerve grafts for nerve regeneration

被引：0
|
作者：
Yao R. [1 ,2 ]
Zhao J. [1 ]
Yan Y. [1 ]
Duan L. [1 ,2 ]
Wang T. [3 ]
Yan J. [1 ,2 ]
Zhang S. [1 ]
Li G. [1 ,2 ]
机构：
[1] College of Textile and Clothing Engineering, Soochow University, Suzhou
[2] National Engineering Laboratory for Modern Silk, Soochow University, Suzhou
[3] Wilson College of Textiles, North Carolina State University, Raleigh
来源：
Fangzhi Xuebao/Journal of Textile Research | 2022年 / 43卷 / 02期
关键词：
Artificial nerve graft; Biodegradability; Magnesium ion; Peripheral nerve repair; Silk fibroin;
D O I：
10.13475/j.fzxb.20210902007
中图分类号：
学科分类号：
摘要：
In order to develop artificial nerve guidance conduits (NGCs) with good mechanical properties and biocompatibility, this paper describes a three-layer composite artificial nerve graft made up with a chitosan coating layer, a braided layer and a fibrous sponge layer using traditional braiding, electrospinning and freeze-drying techniques. The morphology, mechanical properties, biocompatibility and sustained-release properties were investigated, studying the effects of axial yarn, the outer and inner layers and magnesium ion concentration on its performance. The results showed that the prepared NGCs with braided and axial yarns possess good mechanical properties. The radial compressive property of the NGC with 50% deformation is 1.3 N and the axial tensile stress to yarn fracture is 30 N. The sponge layer features an inter-connected porous structure with uniform pore size distribution (0.04-0.08 mm). The magnesium ion in the NGC can be sustainably released for 28 d. When the concentration of magnesium ion solution is 0.02 g/mL, the NGC has the greatest effect on promoting cell proliferation. This paper provides new ideas for selecting materials for NGCs and optimizing their structural properties. © 2022, Periodical Agency of Journal of Textile Research. All right reserved.
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页码：125 / 131
页数：6
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