Determination of Hydroxyethyl Hydrazine Nitrate by Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry

被引：0
|
作者：
Xu L.-N. [1 ]
Zhang X.-J. [1 ]
Zhao T. [1 ]
Li J. [1 ]
Fang T. [1 ]
机构：
[1] Beijing Institute of Aerospace Testing Technology, Beijing
来源：
Hanneng Cailiao/Chinese Journal of Energetic Materials | 2020年 / 28卷 / 09期
关键词：
Hydrophilic interaction chromatography; Hydroxyethyl hydrazine nitrate; Mass spectrometry;
D O I：
10.11943/CJEM2019325
中图分类号：
学科分类号：
摘要：
A method based on hydrophilic interaction chromatography (HILIC) coupled with mass spectrometry (MS) was developed for determination of hydroxyethyl hydrazine nitrate (HEHN). The effects of the composition of mobile phase and parameters for MS detection were investigated on the optimization of chromatography separation, time required for analysis, and detection sensitivity. Good linearity is obtained under the concentration range of 0.01-0.1 μg•mL-1 with R2=0.9991, and the limit of detection of 1.2 ng•mL-1. Recovery of two HEHN samples with concentration of 0.0250 and 0.0900 μg•mL-1 is determined as 98.1% and 97.7%, respectively, while relative standard deviation (RSD) is no more than 1.6%, indicating good precision of the method. A real sample of liquid propellant is determined by this method, and the content of HEHN measured as 12.5%±0.3% is in accordance with the prepared concentration of 12.9%. © 2020, Editorial Board of Chinese Journal of Energetic Materials. All right reserved.
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页码：936 / 941
页数：5
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