Preparation and properties of daidzein microparticles by an ultrasonic assisted anti-solvent method

被引：0
|
作者：
Zhang X. [1 ,3 ]
Huang Y. [2 ]
机构：
[1] School of Life Sciences, Jiaying University, Meizhou
[2] School of Geography and Tourism, Jiaying University, Meizhou
[3] Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, Meizhou
来源：
Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities | 2023年 / 37卷 / 03期
关键词：
anti-solvent method; daidzein microparticles; particle size; response surface optimization; solvent residue;
D O I：
10.3969/j.issn.1003-9015.2023.03.015
中图分类号：
学科分类号：
摘要：
In order to solve the problems of poor water solubility, low bioavailability and limited practical application of natural daidzein, daidzein ultrafine powders were prepared by an ultrasonic assisted anti-solvent method which used natural daidzein as raw material, N, N-dimethylformamide as solvent, and deionized water as antisolvent. Daidzein particle size was studied by single factor experiments, and the results were optimized by Box-Behnken design combined with response surface methodology. The appearance and particle size of the powder was observed by scanning electron microscopy, the properties were analyzed by Fourier Transform infrared spectroscopy and differential calorimetry and the residual solvent concentration of daidzein ultrafine powder was analyzed by gas chromatography. The results show that the best preparation conditions were: solution concentration = 15.83 mgmL1, nozzle diameter = 300 μm, homogenization rate = 3 000 rmin1, volume ratio of inverse solvent to solvent (liquid to liquid) = 9 and ultrasonic power = 144 W. The minimum particle size of daidzein ultrafine powder was 188 nm. Compared with raw powder, the size of ultrafine powder is greatly reduced, the chemical structure is not changed before and after preparation, and the antioxidant activity is significantly increased. © 2023 Zhejiang University. All rights reserved.
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页码：462 / 471
页数：9
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