Rural regional system is a spatial system with certain structure, function and inter-regional relationship, which is composed of humanity, economy, resources and environment that are connected and interacted with each other. It is a regional multi-body system, including urban-rural integrity, rural synthesis, village-town organism, and housing-industry synergy. Targeting the rural regional system and supporting the rural revitalization strategy provides new opportunities and challenges for innovation of Chinese geography in the new era. Guided by the theory of regional system of human-land system and the science of human-land system, the research on rural revitalization geography should serve national strategy by finding solutions to problems hindering rural sustainable development, and make contribution to the comprehensive study of rural regional system structure, transformation process, evolution mechanism, differentiation pattern, regional function, and rural revitalization path and model under the interaction of surface's human-land system. There is an urgent requirement to better understand and reveal differences in the types of rural regional system and their differentiation law. Taking 39164 townships in China as research object, this paper used quantitative and qualitative methods to detect and identify the dominant factors that restrict the sustainable development of rural regional systems in China. Then we divided the types of Chinese rural regional systems, revealed the pattern of rural regional differentiation and further proposed scientific approaches to rural revitalization in different areas. Results demonstrate that topographic conditions, climate conditions, ruralization level, land resources endowment, population mobility and aging level are the dominant factors restricting the sustainable development of rural regional system, of which reflects the level of resource endowment, endogenous power and external aid of rural development. Through cluster analysis and spatial overlay of dominant factors, China's rural regional system can be divided into 12 first-class zones and 43 second-class zones. The first-class zones are named by means of 'geographical location + driving force of dominant factors', and the second-class zones are named by means of 'regional scope + driving force of dominant factors + economic development level'. The driving force of rural sustainable development in different regional types are varied. The regional pattern and path of rural revitalization in different types of areas are varied, and promoting the rural revitalization strategy should be based on local conditions to realize the coordination and sustainable development of rural economy, society, culture and ecosystem. © 2019, Science Press. All right reserved.