Molecular Mechanisms for in Vivo Cholesterol-lowering Effect by Lactobacillus plantarum

被引：0
|
作者：
Jin D. [1 ]
Ma W. [2 ]
机构：
[1] Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin
[2] Heilongjiang University of Chinese Medicine, Harbin
来源：
Journal of Chinese Institute of Food Science and Technology | 2020年 / 20卷 / 03期
关键词：
Cholesterol; Lactobacillus plantarum; Mice; Western blot;
D O I：
10.16429/j.1009-7848.2020.03.007
中图分类号：
学科分类号：
摘要：
Objective: It was evaluated that the effect and genes related to hepatic cholesterol metabolism of Lactobacillus plantarum KLDS strain on the cholesterol metabolism in hyperlipidemia mice. Method: Health C57BL/6 male mice, as objects, were divided into control group, model group, low-dose group, high-dose group and pravastatin group, which were respectively given normal saline, Lactobacillus plantarum KLDS1.0386 bacteria suspension and pravastatin solution by gavage for 4 consecutive weeks. The serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were determined on the 28th day of the experiment. The genes related to hepatic cholesterol metabolism (HMGCR, LDLR, SREBP2, CYP7A1, FXR) were investigated in mice. Results: After 4 weeks administration, compared with mice fed a high-cholesterol diet without lactic acid bacteria supplementation, there was a significant(P<0.05) decrease in TG, the total cholesterol and LDL-C levels in the serum, and the mice fed the KLDS1.0386 diet had significantly (P<0.05) the down-regulation of HMGCR and FXR (P<0.05) and the up-regulation of CYP7A1 (P<0.05). Concluton: Lactobacillus plantarum KLDS1.0386 has probiotic potential as indicated by its hypocholesterolemic effect both in vivo, it could be as the probiotics with cholesterol-lowering activity. © 2020, Editorial Office of Journal of CIFST. All right reserved.
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页码：52 / 57
页数：5
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