Effect of Food with Medicine and Edible Homologous on Ethanol-induced Gastric Mucosal Injury in Rats

被引：0
|
作者：
Pan M. [1 ]
Xu D. [1 ]
Sun Y. [1 ]
Hu J. [1 ]
Nie S. [1 ]
Zhong H. [2 ]
Yao M. [2 ]
Xie M. [1 ]
机构：
[1] State Key Laboratory of Food Science and Technology, Nanchang University, China-Canada Food Science and Technology Joint Laboratory (Nanchang), Nanchang
[2] Jiangxi Jiangzhong Shiliao Science and Technology Co., Ltd., Jiujiang
来源：
Journal of Chinese Institute of Food Science and Technology | 2021年 / 21卷 / 07期
关键词：
Biscuit; Chinese medicine homologous food; Gastric mucosal injury; Hericium erinaceus; Poria cocos; Rice paste; Yam;
D O I：
10.16429/j.1009-7848.2021.07.014
中图分类号：
学科分类号：
摘要：
Objective: The effects of rice paste and biscuit rich in Chinese medicine homologous food extract (rice paste rich in Poria cocos-yam extract, and biscuit rich in Hericium erinaceus extract) on ethanol-induced gastric mucosal injury in rats was investigated in this study. Methods: Acute gastric mucosal injury model was established by orally administering absolute ethanol to rats. Rats were randomly divided into normal group, model group, positive group, three Poria cocos-yam extract treatment groups (low, medium, high dose), three rice paste treatment groups (low, medium, high dose), three Hericium erinaceus extract treatment groups (low, medium, high dose), and three biscuit treatment groups (low, medium, high dose). On this basis, the effects of four test substances on ethanol-induced gastric mucosal injury in rats were further explored (observation of rat growth and gastric mucosal injury). Results: Compared with the normal group, the model group showed obvious bleeding bands, a large number of bleeding locations, gastric mucosal glandular structure disorder, epithelial cell shedding and severe congestion, and significantly increased gastric mucosal injury index. Compared with the model group, the gastric bleeding bands and bleeding locations of rats in each dose group of the four kinds of treatment were significantly reduced. In addition, the gastric mucosal damage for rats was also significantly reduced. Conclusion: The four kinds of treatment have better preventive effects on ethanol-induced acute gastric mucosal injury in rats. Meanwhile, the effect of Poria cocos-yam extract and the rice paste in each dose was better than Hericium erinaceus extract and the biscuit. The results in this study can provide data support for the development of health products for improving gastrointestinal function. © 2021, Editorial Office of Journal of CIFST. All right reserved.
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页码：115 / 122
页数：7
相关论文
共 24 条
  • [1] MEERVELD G V B, JOHNSON A C, GRUNDY D., Gastrointestinal physiology and function, Handbook of Experimental Pharmacology, 239, (2017)
  • [2] 12
  • [3] 6
  • [4] (2018)
  • [5] (2005)
  • [6] LI K, HE C H., Gastric mucosal lesions in tibetans with high-altitude polycythemia show increased HIF-1A expression and ROS production, BioMed Research International, 3, pp. 1-11, (2019)
  • [7] OSOEFAWA T, MINODA Y, IHARA E, Et al., Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized cross-over study, Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society, 31, 4, pp. 413-421, (2019)
  • [8] XU Y, WANG S, CHAN H F, Et al., Dihydromyricetin induces apoptosis and reverses drug resistance in ovarian cancer cells by p53-mediated downregulation of survivin, Scientific Reports, 7, 1, pp. 1-12, (2017)
  • [9] ABDELWAHAB I S., Protective mechanism of gallic acid and its novel derivative against ethanol-induced gastric ulcerogenesis: Involvement of immunomodulation markers, Hsp70 and Bcl-2-associated X protein, International Immunopharmacology, 16, 2, pp. 296-305, (2013)
  • [10] 4
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