Preparation of hexanoyl ethylene glycol chitosan/poloxamer composite hydrogel for drug release

被引：0
|
作者：
Xu W. [1 ]
Zhao L. [2 ]
Zheng Z. [3 ]
Gao L. [1 ]
Li Z. [1 ,4 ,5 ,6 ]
机构：
[1] School of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin
[2] School of Materials Science and Engineering, Tianjin University of Technology, Tianjin
[3] Nanjing Linehome Environmental Protection Technology Co., Ltd., Nanjing
[4] State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai
[5] Tianjin Key Laboratory of Marine Resources and Chemistry, Tianjin University of Science and Technology, Tianjin
[6] Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin
来源：
Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica | 2022年 / 39卷 / 01期
关键词：
Composite hydrogel; Drug release; Hexanoyl glycol chitosan; Injectability; Poloxamer;
D O I：
10.13801/j.cnki.fhclxb.20210302.008
中图分类号：
学科分类号：
摘要：
In order to reduce the dependence of the sol-gel transition temperature of the poloxamer hydrogel on the concentration, the poloxamer (P407) was used as the substrate, and hexanoyl ethylene glycol chitosan (HGC) was compounded with poloxamer to prepare HGC/P407 composite hydrogel. FTIR, SEM and tube inversion method were used to investigate the properties of HGC/P407 composite hydrogel in different mass ratios, and the in vitro drug release performance of HGC/P407 composite hydrogel was characterized by UV-vis spectroscopy. The results show that sol-gel transformation can occur in HGC/P407 hydrogel based on 3% poloxam by controlling the addition of HGC, and the sol-gel transition temperature of HGC/P407 hydrogel is between 32℃ and 37℃. HGC/P407 composite hydrogel has high porosity with interconnected pores which size ranging from 10 to 90 µm. The release amount of the anticancer drug gemcitabine of HGC/P407 composite hydrogel is 82%~90.6%, and the sustained release time can reach about 80 h. HGC/P407 composite hydrogel has important application prospects in the field of injectable drug carriers. Copyright ©2022 Acta Materiae Compositae Sinica. All rights reserved.
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页码：266 / 274
页数：8
相关论文
共 29 条
  • [1] BYEONGMOON J A, SUNG W K B, YOU H B., Thermosensitive sol-gel reversible hydrogels, Advanced Drug Delivery Reviews, 64, 1, pp. 154-162, (2012)
  • [2] MEKONNEN G, EFREM G., Hydrogel-A promising technology for optimization of nutrients and water in agricultural and forest ecosystems, International Journal of Environmental Sciences & Natural Resources, 23, pp. 106-111, (2020)
  • [3] LI Y F, KILIAN K A., Bridging the gap: from 2D cell culture to 3D microengineered extracellular matrices, Advanced Healthcare Materials, 4, 18, pp. 2780-2796, (2016)
  • [4] CONSTANTIN M, BUCATARIU S M, DOROFTEI F, Et al., Smart composite materials based on chitosan microspheres embedded in thermosensitive hydrogel for controlled delivery of drugs, Carbohydrate Polymers, 157, pp. 493-502, (2017)
  • [5] GAO J, LIU R, WU J, Et al., The use of chitosan based hydrogel for enhancing the therapeutic benefits of adipose-derived MSCs for acute kidney injury, Biomaterials, 33, 14, pp. 3673-3681, (2012)
  • [6] SHARMA S, TIWARI S., A review on biomacromolecular hydrogel classification and its applications, International Journal of Biological Macromolecules, 162, pp. 737-747, (2020)
  • [7] ZHENG X, DING Z, CHENG W, Et al., Microskin-inspired injectable MSC-Laden hydrogels for scarless wound healing with hair follicles, Advanced Healthcare Materials, 9, 10, (2020)
  • [8] CHEN Y, QIU Y, WANG Q, Et al., Mussel-inspired sandwich-like nanofibers/hydrogel composite with super adhesive, sustained drug release and anti-infection capacity, Chemical Engineering Journal, 399, (2020)
  • [9] HSIEH H Y, LIN W Y, LEE A L, Et al., Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of poloxamer 407: HA/P407 hydrogel system for drug delivery, Plos One, 15, 3, (2020)
  • [10] DENG Z X, WANG H, GUO B L, Et al., Self-healing conductive hydrogels: preparation, properties and applications, Nanoscale, 12, 3, (2020)
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