Recent advancements in optical biosensors for cancer detection

Optical biosensors are rapid, real-time, and portable, have a low detection limit and a high sensitivity, and have a great potential for diagnosing various types of cancer. Optical biosensors can detect cancer in a few million malignant cells, in comparison to conventional diagnosis techniques that use 1 billion cells in tumor tissue with a diameter of 7 nm–10 nm. Current cancer detection methods are also costly, inconvenient, complex, time consuming, and require technical specialists. This review focuses on recent advances in optical biosensors for early detection of cancer. It is primarily concerned with advancements in the design of various biosensors using resonance, scattering, chemiluminescence, luminescence, interference, fluorescence, absorbance or reflectance, and various fiber types. The development of various two-dimensional materials with optical properties such as biocompatibility, field enhancement, and a higher surface-to-volume ratio, as well as advancements in microfabrication technologies, have accelerated the development of optical sensors for early detection of cancer and other diseases. Surface enhanced Raman spectroscopy technology has the potential to detect a single molecule with high specificity, and terahertz waves are a recently explored technology for cancer detection. Due to the low electromagnetic interference, small size, multiplexing, and remote sensing capabilities of optical fiber-based platforms, they may be a driving force behind the rapid development of biosensors. The advantages and disadvantages of existing and future optical biosensor designs for cancer detection are discussed in detail. Additionally, a prospect for future advancements in the development of optical biosensors for point-of-care and clinical applications is highlighted. © 2021 Elsevier B.V.