Construction and Validation of a Metastasis-Related Prognostic Model for Hepatocellular Carcinoma Patients

被引：0
|
作者：
Liu Y. [1 ,2 ]
Xiong R. [2 ,3 ]
Xiao T. [2 ,3 ]
Yang Y. [4 ]
Liu K. [2 ]
Feng G. [2 ]
Song G. [1 ,2 ]
机构：
[1] School of Basic Medicine, North Sichuan Medical College, Nanchong
[2] Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong
[3] School of Medical Imaging, North Sichuan Medical College, Nanchong
[4] Sichuan Chidingshengtong Biotechnology Co., Ltd, Chengdu
来源：
Dianzi Keji Daxue Xuebao/Journal of the University of Electronic Science and Technology of China | 2022年 / 51卷 / 02期
关键词：
Hepatocellular carcinoma; Metastasis-related genes; Prognostic model; Validation;
D O I：
10.12178/1001-0548.2021301
中图分类号：
学科分类号：
摘要：
Hepatocellular carcinoma is a malignant tumor with high aggressiveness and metastasis. This study aims to construct a predictive model based on metastasis-related genes (MTGs). Cox analysis and Lasso regression analysis were used to build the prognostic model, and the relationship between the risk score of this model and the survival and clinical characteristics of hepatocellular carcinoma (HCC) patients was analyzed. The results of the study constructed a prognostic model containing four MTGs. In the the cancer genome atlas (TCGA) training set, HCC patients in the low-risk group had lower risk scores, fewer deaths and higher 5-year survival (P < 0.01), Cox analysis showed that the model could predict survival of HCC patients independently of other clinical characteristics ( P < 0.01), and the AUC values of 1-, 2- and 3-years were all greater than 0.74 in the time-dependent ROC curve prediction analysis. Meanwhile, the validation set also confirmed the above results. Taken together, we constructed a MTGs prognostic model and it was expected to be an independent prognostic factor for prognostic prediction judgment of HCC patients. Copyright ©2022 Journal of University of Electronic Science and Technology of China. All rights reserved.
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页码：184 / 193
页数：9
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