Adsorption and controlled release behavior for thermosensitive imprinted silica microspheres toward diosgenin

被引：0
|
作者：
Mao L. [1 ]
Xu G. [1 ]
Luo X. [1 ]
Tian H. [1 ]
Li H. [1 ]
机构：
[1] College of Chemistry and Chemical Engineeering, Jishou University, Jishou
来源：
Huagong Jinzhan/Chemical Industry and Engineering Progress | 2022年 / 41卷 / 01期
关键词：
Adsorption; Controlled release; Diosgenin; Molecularly imprinted polymers; Thermosensitive imprinted silica microspheres;
D O I：
10.16085/j.issn.1000-6613.2021-0136
中图分类号：
学科分类号：
摘要：
Studying on the adsorption and controlled release behavior for the molecularly imprinted polymers is of great theoretical and applied value. In present work, a thermosensitive diosgenin imprinted silica microsphere (TMIP) was prepared by a surface imprint technology using silylated silica as the carrier, diosgenin as the template, methacrylic acid(MAA) and N-isopropylacrylamide(NIPAm) as common functional monomers, ethylene glycol dimethacrylate as the cross-linker and azodiisobutyronitrile(AIBN) as the initiator. Superficial chemical groups and particle morphology for this TMIP were characterized by using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). Loaded capacity and controlled release behavior for this TMIP toward diosgenin under different environmental conditions were tested. Results showed that the imprinted microspheres had higher adsorption capacity toward diosgenin, with a saturated adsorption capacity of 21.6mg/g. It was indicated from drug release dynamics that while the imprinted microspheres emerged a high controlled drug release capability, with a diosgenin-releasing percentage of 81.9% within 12h, the non imprinted silica gel microspheres had no sustained-release property. Environmental conditions also had great influence on the controlled release of thermosensitive imprinted silica microspheres, with the maximum release rate of 99.28% when release was performed at 303K in methanol solution with a NaCl-controlled ionic strength of 1.5×10-4mol/L. © 2022, Chemical Industry Press Co., Ltd. All right reserved.
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页码：365 / 372
页数：7
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