Continuous flow oxidation of benzyl alcohol to benzaldehyde

被引：0
|
作者：
Liu J. [1 ,2 ]
Yan S. [1 ,2 ]
Zhang Y. [2 ]
Shen J. [1 ,2 ]
机构：
[1] School of Pharmaceutical and Life Sciences, Changzhou University, Changzhou
[2] Continuous Flow Engineering Laboratory of National Petroleum and Chemical Industry, Changzhou
来源：
Huagong Jinzhan/Chemical Industry and Engineering Progress | 2021年 / 40卷 / 01期
关键词：
Benzaldehyde; Benzyl alcohol; Continuous flow technology; Oxidation reaction; TEMPO catalyst;
D O I：
10.16085/j.issn.1000-6613.2020-0544
中图分类号：
学科分类号：
摘要：
Benzaldehyde was continuously synthesized using benzyl alcohol as raw material and 2, 2, 6, 6-tetramethyl-piperidin-1-oxyl (TEMPO) over catalyst, by the oxidation of sodium hypochlorite solution in a continuous flow micro-channel reactor under the liquid-phase conditions. The effects of reactants molar ratio, amount of catalyst, reaction temperature, solvents and residence time on the yields of product were investigated and the process conditions were optimized. The results indicate that under the conditions of n(NaClO): n(benzyl alcohol)=1.25: 1, n(benzyl alcohol): n(TEMPO)=1: 0.01, V(benzyl alcohol): V(DMF)=1: 10, pH=8, reaction temperature at 0℃, and residence time at 10min, the yield of benzaldehyde reaches 95.1%. © 2021, Chemical Industry Press Co., Ltd. All right reserved.
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页码：394 / 400
页数：6
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