Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains

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LI WeiZhong ZHANG Heng WANG GeFei ZHANG Chi ZENG XiangXing LIU Hui CHEN XiaoXuan XU YanXuan LI KangSheng Department of Microbiology and ImmunologyKey Immunopathology Laboratory of Guangdong ProvinceShantou University Medical CollegeShantou China Department of Veterinary MedicineUniversity of MarylandCollege ParkMD USA Department of UltrasonicCentral Hospital of Luoyang CityLuoyang China [1 ,2 ,1 ,1 ,1 ,1 ,3 ,1 ,1 ,1 ,1 ,515041 ,2 ,20742 ,3 ,471009 ]
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Science China(Life Sciences) | 2012年 / 55卷 / 06期
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摘要：
Non-structural protein 1(NS1) of the influenza virus plays a crucial role in modulating the host immune response and facilitating virus replication.The formation of a homodimer or an oligomer is necessary for NS1 to exert its function efficiently.In the present study,the NS1 protein from the A/Shantou/602/06(H3N2) virus(herein abbreviated as NS32) was found to interact with NS1 from A/Shantou/169/06(H1N1),A/Chicken/Guangdong/1/05(H5N1) and A/Quail/Hong Kong/G1/97(H9N2)(abbreviated as NS11,NS51 and NS92,respectively) viruses,although NS32 shares 17.4% 20.9% sequence diversity with NS11,NS51 and NS92.This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains may be a common event during co-infection.
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页码：507 / 515
页数：9
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