ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency

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作者：
Xin Huang [1 ]
Nazym Bashkenova [1 ]
Jihong Yang [1 ]
Dan Li [1 ,2 ]
Jianlong Wang [1 ]
机构：
[1] Department of Medicine, Columbia Center for Human Development, Columbia University Irving Medical Center
[2] Department of Cell, Developmental and Regenerative Biology,Black Family Stem Cell Institute, Icahn School of Medicine at Mount
来源：
Protein & Cell. | 2021年 / 12卷 / 03期
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摘要：
<正>Dear Editor,Cell-fate decisions are governed by comprehensive generegulatory programs. During the preimplantation development, at least two waves of cell fate decisions are made while the cells gradually lose their totipotency(Schrode et al., 2013). The flrst decision involves the spatial separation of outer-residing trophectoderm(TE) cells from inner cell mass(ICM) in E3.5 mouse blastocyst.
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