Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase

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作者：
Yechun Xu [1 ,2 ]
Hualiang Jiang [1 ,2 ,3 ]
机构：
[1] CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
[2] University of Chinese Academy of Sciences
[3] Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech
来源：
Protein & Cell. | 2020年 / 11卷 / 10期
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摘要：
<正>The ongoing pandemic of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2), referred to as coronavirus disease 2019(COVID-19), has caused over 13 million infections and over 560,000 deaths worldwide(https://www.who.int/emergencies/diseases/novel-coronavirus-2019/sit uation-reports), posing a significant threat to globally public health and economics. At present, no efficacious antiviral drugs and vaccines have been approved for the prophylaxis or treatment of COVID-19.
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