Au(III)/TPPMS-catalyzed Friedel-Crafts benzylation of deactivated N-alkylanilines in water

被引：1

作者：

Hikawa, Hidemasa ^{[1
]}

Fukuda, Akane ^{[1
]}

Kondo, Kazuma ^{[1
]}

Nakayama, Taku ^{[1
]}

Enda, Tomokatsu ^{[1
]}

Kikkawa, Shoko ^{[1
]}

Azumaya, Isao ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 38期

基金：

日本学术振兴会;

关键词：

HOFMANN-MARTIUS REARRANGEMENT; ALKYLATION; ACYLATION;

D O I：

10.1039/d4ob01234h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Friedel-Crafts reaction of electronically deactivated anilines including those with strong electron-withdrawing NO2, CN or CO2H groups is challenging due to the reduced electron density of the aromatic ring. Here, we demonstrate the Au(iii)/TPPMS-catalyzed Friedel-Crafts benzylation of deactivated anilines in water. This reaction exhibits operational simplicity and a broad substrate scope with high regioselectivity, enabling rapid access to 2-benzylanilines.

引用

页码：7874 / 7879

页数：6

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