Immunogenicity and protective efficacy of the HC009 mRNA vaccine against SARS-CoV-2

被引：2
|
作者：
Liu, Juan [1 ]
Han, Huafeng [1 ]
Yang, Binbin [1 ]
Zhang, Naifang [1 ]
Li, Jing [1 ]
Chen, Xicheng [1 ]
Wu, Jie [1 ]
Zhao, Yingying [1 ]
Yang, Yongsheng [1 ]
机构：
[1] Zhejiang Haichang Biotech Co Ltd, Nucl Acid Med Innovat Ctr, Hangzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词：
mRNA vaccine; SARS-CoV-2; immunogenicity; prime-boost; humoral immunity; immune protection; SPIKE;
D O I：
10.3389/fimmu.2024.1416375
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
With the rapid global spread of COVID-19 and the continuous emergence of variants, there is an urgent need to develop safe and effective vaccines. Here, we developed a novel mRNA vaccine, HC009, based on new formulation by the QTsome delivery platform. Immunogenicity results showed that the prime-boost immunization strategy with HC009 was able to induce robust and durable humoral immunity, as well as Th1-biased cellular responses in rodents or non-human primates (NHPs). After further challenge with live SARS-CoV-2 virus, HC009 provided adequate protection against virus infection in hACE2 transgenic mice. Therefore, HC009 could provide significant immune protection against SARS-CoV-2.
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页数：14
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