Engineered extracellular vesicles containing endogenous retrovirus-like capsids-a glimpse into the future of gene therapy

被引：0
|
作者：
Xu, Yiru [1 ,2 ]
Wang, Juan [3 ]
Saiding, Qimanguli [3 ]
Cui, Wenguo [3 ]
Chen, Xinliang [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai 200030, Peoples R China
[2] Shanghai Key Lab Embryo Original Dis, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Sch Med,Dept Orthopaed,Shanghai Key Lab Prevent &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
来源：
MATTER | 2024年 / 7卷 / 08期
关键词：
D O I：
10.1016/j.matt.2024.04.008
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Extracellular vesicles (EVs) are potential gene therapy platforms, yet their therapeutic use is hindered by low encapsulation efficiency and weak targeting specificity. A recent Nature Biomedical Engineering study reports the retrovirus-like EVs for efficient mRNA delivery the CNS, showing considerable promise for systematic, targeted, and efficient gene therapy.
引用
收藏
页码：2628 / 2630
页数：3
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