Resistance to fracture of simulated immature teeth treated with intracanal medicaments and calcium silicate-based coronal barrier materials in endodontic regeneration

The current study aimed to evaluate the resistance to fracture of simulated immature teeth treated with different intracanal medicaments and calcium silicate-based coronal barrier materials used in endodontic regeneration. One hundred five extracted maxillary central incisors were selected. Five teeth were assigned to the positive control group. The cavities of the other teeth (n = 100) were prepared, and the root canals were instrumented with Peeso reamers. Ten teeth were assigned to the negative control group where no medication applicated. The remaining 90 teeth were randomly distributed in three different intracanal medication groups as follows (n = 30/group): Group (1) Calcium hydroxide; Group (2) Double antibiotic paste; Group (3) Triple antibiotic paste. Afterward, each group was further divided into subgroups (n = 15 for the experimental groups, n = 5 for the negative control group) based on the coronal barrier material used: (1) MTA and (2) Biodentine. Each specimen was subjected to fracture testing. The specimens were inspected using a stereomicroscope and classified as restorable or non-restorable based on the fracture type. No significant difference in fracture resistance or fracture type was observed between the groups treated with different intracanal medicaments or calcium silicate-based coronal barrier materials (p > 0.05). Different intracanal medicaments (calcium hydroxide, double antibiotic paste, triple antibiotic paste) and calcium silicate-based coronal barrier materials (MTA, Biodentine) can be used as alternatives to each other in terms of their effect on fracture resistance in immature teeth.