Infection Rates After Aseptic Revision Total Hip Arthroplasty With Extended Oral Antibiotic Prophylaxis

被引:0
|
作者
Mohiuddin, Amer [1 ]
Rice, Justin [2 ]
Ziemba-Davis, Mary [3 ]
Meneghini, R. Michael [4 ]
机构
[1] Indiana Univ, Sch Med, Dept Anesthesia, Indianapolis, IN USA
[2] Ascension St Vincent Hosp, Dept Family Med, Ascens St, Indianapolis, IN USA
[3] Indiana Univ Hlth Multispecialty Musculoskeletal C, Carmel, IN USA
[4] Indiana Univ, Dept Orthopaed Surg, Sch Med, Indianapolis, IN 47405 USA
关键词
TOTAL JOINT ARTHROPLASTY; REDUCE REINFECTION; KNEE ARTHROPLASTY; MARK COVENTRY; COMPLICATIONS; EPIDEMIOLOGY; MULTICENTER; RESISTANCE; OUTCOMES; SURGERY;
D O I
10.5435/JAAOS-D-23-00750
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Introduction:Few US studies have investigated the efficacy of extended oral antibiotic prophylaxis (EOAP) in the prevention of periprosthetic joint infection (PJI) after aseptic revision total hip arthroplasty (R-THA). This study compared PJI rates in aseptic R-THA performed with EOAP with PJI rates in published studies of aseptic R-THA patients not receiving EOAP.Methods:Prospectively documented data on 127 consecutive aseptic R-THAs were retrospectively reviewed. Evidence-based perioperative infection prevention protocols were used, and all patients were discharged on 7-day EOAP. Superficial and deep infections at 30 and 90 days postoperatively and at mean latest follow-up of 27.8 months were statistically compared with all US studies reporting the prevalence of PJI after aseptic R-THA. Complications related to EOAP within 120 days of the index procedure also are reported.Results:No superficial or deep infections were observed at 30 and 90 days postoperatively when 7-day postdischarge EOAP was used. Superficial and deep infection rates were 1.57% (two patients) and 3.15% (four patients) at mean latest follow-up, respectively. Comparisons with published 30-day PJI rates of 1.37% (P = 0.423) and 1.85% (P = 0.257) were not statistically significant. Two of four comparisons with published 90-day PJI rates of 3.43% (P = 0.027) and 5.74% (P = 0.001) were statistically different. The deep PJI rate of 3.15% at mean latest follow-up was significantly lower than two of three published rates at equivalent follow-up including 10.10% (P = 0.009) and 9.12% (P = 0.041). No antibiotic-related complications were observed within 120 days of the index procedure.Discussion:Study findings possibly support the use of EOAP after aseptic R-THA to prevent catastrophic PJI with revision implants, indicating that the efficacy of EOAP cannot be definitively ruled-in or ruled-out based on available evidence.
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页码:472 / 480
页数:9
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