In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics

被引：0
|
作者：
Zhang, Furu [1 ]
Kovalick, Katherine [1 ]
Raghavendra, Achyut [1 ]
Soltanian-Zadeh, Somayyeh [1 ,2 ]
Farsiu, Sina
Hammer, Daniel X. [1 ]
Liu, Zhuolin [1 ]
机构：
[1] US FDA, Ctr Devices & Radiol Hlth CDRH, Silver Spring, MD 20993 USA
[2] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2024年 / 15卷 / 08期
基金：
美国国家卫生研究院;
关键词：
SUBRETINAL DRUSENOID DEPOSITS; SCANNING LASER OPHTHALMOSCOPY; HIGH-RESOLUTION; AUTOFLUORESCENCE; OCT; SUPERRESOLUTION; DEGENERATION; NEURONS; IMAGES;
D O I：
10.1364/BOE.533249
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Retinal ganglion cells play an important role in human vision, and their degeneration results in glaucoma and other neurodegenerative diseases. Imaging these cells in the living human retina can greatly improve the diagnosis and treatment of glaucoma. However, owing to their translucent soma and tight packing arrangement within the ganglion cell layer (GCL), successful imaging has only been achieved with sophisticated research-grade adaptive optics (AO) systems. For the first time we demonstrate that GCL somas can be resolved and cell morphology can be quantified using non-AO optical coherence tomography (OCT) devices with optimal parameter configuration and post-processing. (c) 2024 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
引用
收藏
页码：4675 / 4688
页数：14
相关论文
共 50 条
  • [1] In vivo imaging of retinal ganglion cells in the human eye with adaptive optics optic coherence tomography
    Kadomoto, Shin
    Uji, Akihito
    Muraoka, Yuki
    Tamiya, Ryosuke
    Nozato, Koji
    Tsujikawa, Akitaka
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [2] Imaging human retinal pigment epithelium cells using adaptive optics optical coherence tomography
    Liu, Zhuolin
    Kocaoglu, Omer P.
    Turner, Timothy L.
    Miller, Donald T.
    [J]. OPHTHALMIC TECHNOLOGIES XXVI, 2016, 9693
  • [3] Adaptive optics optical coherence tomography for in vivo mouse retinal imaging
    Jian, Yifan
    Zawadzki, Robert J.
    Sarunic, Marinko V.
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2013, 18 (05)
  • [4] Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
    Jagodzinska, Jolanta
    Sarzi, Emmanuelle
    Cavalier, Melanie
    Seveno, Marie
    Baecker, Volker
    Hamel, Christian
    Pequignot, Marie
    Delettre, Cecile
    [J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, (127):
  • [5] Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice
    Jian, Yifan
    Xu, Jing
    Gradowski, Martin A.
    Bonora, Stefano
    Zawadzki, Robert J.
    Sarunic, Marinko V.
    [J]. BIOMEDICAL OPTICS EXPRESS, 2014, 5 (02): : 547 - 559
  • [6] Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomography
    Zawadzki, Robert J.
    Choi, Stacey S.
    Fuller, Alfred R.
    Evans, Julia W.
    Hamann, Bernd
    Werner, John S.
    [J]. OPTICS EXPRESS, 2009, 17 (05): : 4084 - 4094
  • [7] Imaging retinal nerve fiber bundles using optical coherence tomography with adaptive optics
    Kocaoglu, Omer P.
    Cense, Barry
    Jonnal, Ravi S.
    Wang, Qiang
    Lee, Sangyeol
    Gao, Weihua
    Miller, Donald T.
    [J]. VISION RESEARCH, 2011, 51 (16) : 1835 - 1844
  • [8] Progress on developing wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice
    Zam, Azhar
    Zhang, Pengfei
    Jian, Yifan
    Sarunic, Marinko V.
    Bonora, Stefano
    Pugh, Edward N., Jr.
    Zawadzki, Robert J.
    [J]. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XIX, 2015, 9312
  • [9] Imaging Retinal Capillaries Using Ultrahigh-Resolution Optical Coherence Tomography and Adaptive Optics
    Wang, Qiang
    Kocaoglu, Omer P.
    Cense, Barry
    Bruestle, Jeremy
    Jonnal, Ravi S.
    Gao, Weihua
    Miller, Donald T.
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (09) : 6292 - 6299
  • [10] In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography
    Wong, Kevin S. K.
    Jian, Yifan
    Cua, Michelle
    Bonora, Stefano
    Zawadzki, Robert J.
    Sarunic, Marinko V.
    [J]. BIOMEDICAL OPTICS EXPRESS, 2015, 6 (02): : 580 - 590
12345