The role of tazarotene-induced gene 1 in carcinogenesis: is it a tumor suppressor gene or an oncogene?

被引：0
|
作者：
Wang, Chun-Hua [1 ,2 ]
Wang, Lu-Kai [3 ]
Shyu, Rong-Yaun [4 ]
Tsai, Fu-Ming [5 ]
机构：
[1] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Dermatol, New Taipei 231, Taiwan
[2] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan
[3] Minist Sci & Technol, Dept Life Sci, Taipei 106, Taiwan
[4] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Internal Med, New Taipei 231, Taiwan
[5] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Res, New Taipei 231, Taiwan
来源：
BIOCELL | 2024年 / 48卷 / 09期
关键词：
Tazarotene-induced gene 1; Retinoic acid receptor responder protein 1; Tumor suppressor gene; Oncogene; INFLAMMATORY BREAST-CANCER; RETINOID RESPONSE GENE; PLASMINOGEN-ACTIVATOR; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; ALLELE LOSS; ACID; TIG1; METASTASIS; EXPRESSION;
D O I：
10.32604/biocell.2024.053746
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Tazarotene-induced gene 1 (TIG1) is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer. TIG1 is widely expressed in various tissues; yet in many cancer tissues, it is not expressed because of the methylation of its promoter. Additionally, the expression of TIG1 in cancer cells inhibits their growth and invasion, suggesting that TIG1 acts as a tumor suppressor gene. However, in some cancers, poor prognosis is associated with TIG1 expression, indicating its protumor growth characteristics, especially in promoting the invasion of inflammatory breast cancer cells. This review comprehensively summarizes the roles of the TIG1 gene in cancer development and details the mechanisms through which TIG1 regulates cancer development, with the aim of understanding its various roles in cancer development.
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收藏
页码：1285 / 1297
页数：13
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