Role of Telomere Length in Radiation Response of Hematopoietic Stem & Progenitor Cells in Newborns

被引：0

作者：

Biswas, Angshuman ^{[1
]}

Bhattacharya, Mandar ^{[1
]}

Ghosh, Priyanka ^{[1
]}

Dey, Subrata Kumar ^{[1
]}

机构：

[1] Maulana Abul Kalam Azad Univ Technol, Sch Biotechnol & Biol Sci, Dept Biotechnol, BF-142,Sect 1, Kolkata 700064, W Bengal, India

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2024年

关键词：

Hematopoietic stem cells; ionizing radiation; telomere length; colony forming units; myeloid progenitors; UMBILICAL-CORD BLOOD; IONIZING-RADIATION; DNA-REPAIR; INDIVIDUAL-DIFFERENCES; STEM/PROGENITOR CELLS; GENE-EXPRESSION; POOLED ANALYSIS; IN-UTERO; RADIOSENSITIVITY; SENSITIVITY;

D O I：

10.1080/15513815.2024.2381752

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: Wide inter-individual variations in ionizing radiation (IR) responses of neonatal hematopoietic system calls for identifying reliable biomarkers to effectively estimate radiation exposure damages in neonates. Methods: Association between telomere length (TL) at birth and radiation sensitivity of cord blood hematopoietic stem cells (HSC) from 166 healthy newborns were investigated by assessing their clonogenic differentiation. TL was determined as terminal restriction fragment (TRF) by Southern blot method. Results: TL correlated with surviving fractions of total progenitor colony forming cell (CFC) content at 0.75 Gy (p < 0.05), granulo-macrophagic lineage colony forming units (CFU-GM) at 0.75 Gy (p < 0.05) and erythroid burst forming unit (BFU-E) at 0.75 Gy (p < 0.05) & at 3 Gy (p < 0.05) of newborns. Conclusion: Our results indicate risks for HSC clonogenic survival in neonates with shorter telomeres after IR exposure. These observations might aid in considering TL at birth as an assessment factor for radiation related hematopoietic challenges in children.

引用

页数：15

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