Dynamic ensemble balance in direct- and indirect-pathway striatal projection neurons underlying decision-related action selection

被引:1
|
作者
Tang, Shunhang [1 ,2 ]
Cui, Lele [1 ,2 ]
Pan, Jingwei [1 ]
Xu, Ning-long [1 ,2 ,3 ]
机构
[1] Chinese Acad Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Key Lab Brain Cognit & Brain inspired Intelligence, Shanghai 200031, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Shanghai Ctr Brain Sci & Brain Inspired Intelligen, Shanghai 201210, Peoples R China
来源
CELL REPORTS | 2024年 / 43卷 / 09期
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
BASAL GANGLIA CIRCUITS; CORTEX; ORGANIZATION; ACTIVATION; OPPONENT; MODELS;
D O I
10.1016/j.celrep.2024.114726
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The posterior dorsal striatum (pDS) plays an essential role in sensory-guided decision-making. However, it remains unclear how the antagonizing direct- and indirect-pathway striatal projection neurons (dSPNs and iSPNs) work in concert to support action selection. Here, we employed deep-brain two-photon imaging to investigate pathway-specific single-neuron and population representations during an auditory-guided decision-making task. We found that the majority of pDS projection neurons predominantly encode choice information. Both dSPNs and iSPNs comprise divergent subpopulations of comparable sizes representing competing choices, rendering a multi-ensemble balance between the two pathways. Intriguingly, such ensemble balance displays a dynamic shift during the decision period: dSPNs show a significantly stronger preference for the contraversive choice than iSPNs. This dynamic shift is further manifested in the inter- neuronal coactivity and population trajectory divergence. Our results support a balance-shift model as a neuronal population mechanism coordinating the direct and indirect striatal pathways for eliciting selected actions during decision-making.
引用
收藏
页数:20
相关论文
共 3 条
  • [1] Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
    Wall, Nicholas R.
    De La Parra, Mauricio
    Callaway, Edward M.
    Kreitzer, Anatol C.
    NEURON, 2013, 79 (02) : 347 - 360
  • [2] Evidence for differential cortical input to direct pathway versus indirect pathway striatal projection neurons in rats
    Lei, WL
    Jiao, Y
    Del Mar, N
    Reiner, A
    JOURNAL OF NEUROSCIENCE, 2004, 24 (38): : 8289 - 8299
  • [3] Spatiotemporal patterns of direct and indirect pathway striatal projection neurons in mouse model of Parkinson's disease and dyskinesia
    Alcacer, C.
    Mendonca, M.
    Klaus, A.
    Cenci, M. A.
    Costa, R.
    MOVEMENT DISORDERS, 2018, 33 : S799 - S799