Outpatient ATG-free hematopoietic transplantation for aplastic anemia in limited-resource environments offers excellent results: Data from a single LATAM center

被引：0

作者：

Jaime-Perez, Jose Carlos ^{[1
]}

Gonzalez-Trevino, Mariana ^{[1
]}

Gomez-De Leon, Andres ^{[1
]}

Campos-Bocardo, Miguel A. ^{[1
]}

Barragan-Longoria, Renata V. ^{[1
]}

Cantu-Rodriguez, Olga Graciela ^{[1
]}

Gutierrez-Aguirre, Cesar Homero ^{[1
]}

Gomez-Almaguer, David ^{[1
]}

机构：

[1] Univ Autonoma Nuevo Leon, Dr Jose Eleuterio Gonzalez Univ Hosp, Sch Med, Hematol Dept,Internal Med Div, Monterrey, Mexico

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2024年 / 109卷

关键词：

Severe aplastic anemia; Hematopoietic cell transplant; Outpatient HSCT; Ambulatory transplant; Peripheral blood HSCT; T -cell replete graft; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; SIBLING DONOR TRANSPLANTS; REAL-WORLD DATA; PERIPHERAL-BLOOD; CYCLOPHOSPHAMIDE; EXPERIENCE; DIAGNOSIS;

D O I：

10.1016/j.bcmd.2024.102885

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To document the results of outpatient hematopoietic stem cell transplantation (HSCT) from the peripheral blood (PB) of sibling donors without anti-thymocyte globulin (ATG) in the conditioning regimen. Material and methods: Patients from a low-income population with severe AA who received a PB, unmanipulated sibling HLA-identical HSCT between 2000 and 2020 at a single institution were studied. Survival was the primary outcome. Results: Forty-one transplants were performed. Time between diagnosis and transplant was five months (1-104). Median age was 37 (range, 4-61) years; 25 (61 %) recipients were males and 32 (78 %) had treatment failure, 9 (22 %) have not received treatment. ATG was administered in 5 (12.2 %) cases; the graft source was PB in 38 (92.7 %) transplants. Twenty-six (63.4 %) transplants were carried out in the outpatient setting. Infections developed in 14 (34.1 %) patients. Primary graft failure (GF) occurred in 3 (7.3 %) patients. The 15-year OS was 81 %, EFS was 77.4 %. Patients with high pre-HSCT transfusion burden had lower OS (p = 0.035) and EFS (p = 0.026). Previous treatment failure and age were not associated with lower OS (p = 0.115, p = 0.069) or EFS (p = 0.088, p = 0.5, respectively). Conclusions: HLA-identical T-cell replete outpatient HSCT from the PB of sibling donors for AA patients using ATG-free conditioning offers excellent long-term survival.

引用

页数：6