Recent advances in point-of-care biosensors for pancreatic diseases

Diagnosing and managing life-threatening pancreatic diseases is a costly affair. This article comprehensively reviews the integration, advancements, and future perspectives of Point-of-Care (POC) biosensors investigated for diagnosing pancreatic diseases, including diabetes mellitus, pancreatic cancer, and pancreatitis. Biomarkers play a critical role in the early detection and management of these diseases. Some biomarkers discussed are alpha-amylase, lipase, and carbohydrate antigen 19-9 (CA 19-9). Based on these biomarkers, we explore different categories of biosensors such as electrochemical, optical, and piezoelectric that facilitate rapid and precise detection, and their possible applications in a POC setting. Despite facing challenges like the need for enhanced sensitivity and selectivity, POC biosensors hold significant potential to revolutionize clinical practice. They offer real-time, rapid diagnostic data, which is especially beneficial in resource-limited settings. The review will be beneficial for the researchers, and scientists working on the diagnosis, treatments, and management of these pancreatic diseases.