High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders

被引：5

作者：

Ashraf, Mohammad Vikas ^{[1
]}

Khan, Sajid ^{[2
]}

Misri, Surya ^{[3
]}

Gaira, Kailash S. ^{[4
]}

Rawat, Sandeep ^{[4
]}

Rawat, Balwant ^{[5
]}

Khan, M. A. Hannan ^{[6
]}

Shah, Ali Asghar ^{[6
]}

Asgher, Mohd ^{[2
]}

Ahmad, Shoeb ^{[1
]}

机构：

[1] Baba Ghulam Shah Badshah Univ, Sch Biosci & Biotechnol, Dept Biotechnol, Rajouri 185234, Jammu & Kashmir, India

[2] Baba Ghulam Shah Badshah Univ, Sch Biosci & Biotechnol, Dept Bot, Rajouri 185234, Jammu & Kashmir, India

[3] Baba Ghulam Shah Badshah Univ, Sch Biosci & Biotechnol, Sect Microbiol, Rajouri 185234, Jammu & Kashmir, India

[4] GB Pant Natl Inst Himalayan Environm, Sikkim Reg Ctr, Gangtok 737101, Sikkim, India

[5] Graph Era Univ, Sch Agr, Dehra Dun 248007, Utarakhand, India

[6] Baba Ghulam Shah Badshah Univ, Sch Biosci & Biotechnol, Dept Zool, Rajouri 185234, Jammu & Kashmir, India

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 08期

关键词：

antioxidant; high-altitude medicinal plants; lifestyle-associated disorders; oxidative stress; phytochemicals; ROS; ESSENTIAL OIL COMPOSITION; SALVIA-OFFICINALIS L; ANTIINFLAMMATORY ACTIVITIES; ROOT EXTRACT; HEPATOPROTECTIVE ACTIVITY; ASTRAGALUS-MEMBRANACEUS; CHEMICAL-CONSTITUENTS; MOLECULAR-MECHANISMS; CYTOTOXIC ACTIVITIES; DISEASE PREVENTION;

D O I：

10.3390/ph17080975

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity and human health. Generated during mitochondrial respiration, inflammation, UV exposure and pollution, these species damage cells and contribute to pathologies like cardiovascular issues, neurodegeneration, cancer, and metabolic syndromes. Lifestyle factors exert a substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation and cellular equilibrium. Phytochemicals, abundant in plants, such as carotenoids, ascorbic acid, tocopherols and polyphenols, offer diverse antioxidant mechanisms. They scavenge free radicals, chelate metal ions, and modulate cellular signalling pathways to mitigate oxidative damage. Furthermore, plants thriving in high-altitude regions are adapted to extreme conditions, and synthesize secondary metabolites, like flavonoids and phenolic compounds in bulk quantities, which act to form a robust antioxidant defence against oxidative stress, including UV radiation and temperature fluctuations. These plants are promising sources for drug development, offering innovative strategies by which to manage oxidative stress-related ailments and enhance human health. Understanding and harnessing the antioxidant potential of phytochemicals from high-altitude plants represent crucial steps in combating oxidative stress-induced disorders and promoting overall wellbeing. This study offers a comprehensive summary of the production and physio-pathological aspects of lifestyle-induced oxidative stress disorders and explores the potential of phytochemicals as promising antioxidants. Additionally, it presents an appraisal of high-altitude medicinal plants as significant sources of antioxidants, highlighting their potential for drug development and the creation of innovative antioxidant therapeutic approaches.

引用

页数：61