Characterization and cytotoxicity, antioxidant, and anti-lung carcinoma effects of Matricaria chamomilla extract green-synthesized Ag nanoparticles: Describing a modern chemotherapeutic supplement

Matricaria chamomilla, utilized as an ethnomedicinal plant in Chinese traditional medicine, boasts numerous therapeutic benefits within this ancient healing practice. The medicinal plant, which is rich in antioxidants, can safeguard body cells against a range of damage and lower the chances of developing cancer. Additionally, the plant contains antioxidant compounds that aid in cell regeneration and lower the risk of heart disease as well as various forms of cancer. In recent times, utilizing silver nanoparticles, facilitated by ethno medicinal plants, has gained prominence in the cancers treatment. Here, we examined the silver nanoparticles that were mediated in a green manner following the principles of green chemistry, utilizing the M. chamomilla leaf aqueous extract for the purpose of treating lung carcinoma in an in vitro setting. An assessment was conducted on the effectiveness of silver nanoparticles on various lung cancer cells such as HLC-1, LC-2/ad, and PC-14. Various methods including XRD, FE-SEM, UV-Vis, and TEM were utilized to characterize the silver nanoparticles synthesized through green methods. The spherical morphology of the nanoparticles, ranging in size from 10 to 70 nm, has been verified by the FE-SEM and TEM findings. A higher inhibition percentage was observed as nanoparticles concentration increased, as indicated by the DPPH analysis findings. Among the nanoparticles examined, those at 1000 mu g/ml demonstrated the greatest antioxidant efficacy, displaying an inhibition percentage close to 100 %. Silver nanoparticles exhibited an antioxidant IC50 value of 37 mu g/mL. The silver nanoparticles exhibited IC50 values of 45, 15, and 14 on HLC-1, LC-2/ad, and PC-14, respectively. Following the completion of clinical trial studies, these newly developed nanoparticles hold promise as a potential anti-lung supplement for human use.