Methionine-enabled peptide modification through late-stage Pd-catalyzed β-C(sp3)-H olefination/cyclization

被引：1
|
作者：
Lu, Fengjie [1 ]
Zhang, Xinyi [1 ]
Geng, Yujie [1 ]
Wang, Huihui [1 ]
Tang, Jian [1 ,2 ,3 ]
机构：
[1] Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Catalyt Convers & Clean Energy Univ Shando, Qufu 273165, Peoples R China
[2] Zhejiang Sci Tech Univ Shengzhou Innovat Res Inst, Shengzhou 312400, Peoples R China
[3] Zhejiang Zhongxin Fluoride Mat Co LTD, Shangyu 312369, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 61期
基金：
中国博士后科学基金;
关键词：
ACTIVATED PROTEIN-KINASE; C(SP(3))-H ARYLATION; CYCLIC-PEPTIDES; OLEFINATION; FUTURE; AMINES;
D O I：
10.1039/d4cc02739f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present a method for site-selective diversification of peptides via Pd-catalyzed beta-C(sp(3))-H olefination/cyclization. In this protocol, the native methionine residue acts as a directing group, enabling site-specific olefination/cyclization of peptides. This chemistry demonstrates broad substrate scope, offering a versatile tool for peptide ligation.
引用
收藏
页码：7942 / 7945
页数：4
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