Differential Impact of Serotonin Signaling Methylphenidate on Young versus Adult: Insights from Behavioral and Dorsal Raphe Nucleus Neuronal Recordings from Freely Behaving Rats

被引:0
|
作者
Dafny, Nachum [1 ]
Elizondo, Gloria M. [1 ]
Perez-Vasquez, Cruz [2 ]
机构
[1] Univ Texas Hlth Sci Ctr, McGovern Med Sch, Dept Neurobiol & Anat, Houston, TX 77030 USA
[2] Univ Nacl Autonoma Mexico, Med Sch, Physiol Dept, Mexico City 04510, Mexico
关键词
age differences; behavior; dorsal raphe nucleus; neuronal activity; serotonin; methylphenidate; DEFICIT HYPERACTIVITY DISORDER; PRESCRIPTION STIMULANTS; PREFRONTAL CORTEX; SUBSTANCE-P; DOPAMINE; COCAINE; NOREPINEPHRINE; CHILDREN; ATOMOXETINE; PREVALENCE;
D O I
10.3390/ijms25158082
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Methylphenidate (MPD) remains a cornerstone pharmacological intervention for managing ADHD, yet its increasing usage among ordinary youth and adults outside clinical contexts necessitates a thorough investigation into its developmental effects. This study seeks to simultaneously investigate the behavioral and neuronal changes within the dorsal raphe (DR) nucleus, a center of serotonergic neurons in the mammalian brain, before and after the administration of varying doses of acute and chronic MPD in freely behaving young and adult rats implanted with DR recording electrodes. Wireless neuronal and behavioral recording systems were used over 10 consecutive experimental days. Eight groups were examined: saline, 0.6, 2.5, and 10.0 mg/kg MPD for both young and adult rats. Six daily MPD injections were administered on experimental days 1 to 6, followed by a three-day washout period and MPD re-administration on experimental day 10 (ED10). The analysis of neuronal activity recorded from 504 DR neurons (DRNs) in young rats and 356 DRNs in adult rats reveals significant age-dependent differences in acute and chronic MPD responses. This study emphasizes the importance of aligning electrophysiological evaluations with behavioral outcomes following extended MPD exposure, elucidating the critical role of DRNs and serotonin signaling in modulating MPD responses and delineating age-specific variations in young versus adult rat models.
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页数:25
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