The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression

被引：13

作者：

Malakoti, Faezeh ^{[1
,2
]}

Alemi, Forough ^{[1
]}

Younesi, Simin ^{[3
]}

Majidinia, Maryam ^{[4
]}

Yousefi, Bahman ^{[1
]}

Morovat, Pejman ^{[5
]}

Khelghati, Nafiseh ^{[1
]}

Maleki, Masoomeh ^{[1
]}

Karimian, Ansar ^{[5
]}

Asemi, Zatollah ^{[6
]}

机构：

[1] Tabriz Univ Med Sci, Fac Med, Dept Biochem & Clin Labs, Tabriz, Iran

[2] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

[3] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia

[4] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

[5] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol, Iran

[6] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

来源：

DNA REPAIR | 2021年 / 98卷

关键词：

DNA repair; DNA damage; Noncoding RNA; ATM; AIR;

D O I：

10.1016/j.dnarep.2020.103036

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The DNA damage response (DDR) pathway's primary purpose is to maintain the genome structure's integrity and stability. A great deal of effort has done to understand the exact molecular mechanisms of non-coding RNAs, such as lncRNA, miRNAs, and circRNAs, in distinct cellular and genomic processes and cancer progression. In this regard, the ncRNAs possible regulatory role in DDR via modulation of key components expression and controlling repair signaling pathway activation is validated. Therefore, in this article, we will discuss the latest developments of ncRNAs contribution in different aspects of DNA repair through regulation of ATM-ATR, P53, and other regulatory signaling pathways.

引用

页数：12

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