Structural brain differences in patients with schizophrenia spectrum disorders with and without auditory verbal hallucinations

被引:1
|
作者
Ysbaek-Nielsen, Alexander Tobias [1 ]
Gogolu, Rubina Fray [1 ]
Tranter, Maya [1 ]
Obel, Zacharias Kalle [1 ]
机构
[1] Univ Copenhagen, Dept Psychol, Copenhagen, Denmark
关键词
Schizophrenia spectrum disorders; Auditory verbal hallucinations; Structural MRI; Freesurfer; ANTERIOR CINGULATE CORTEX; HUMAN CEREBRAL-CORTEX; SCHIZOAFFECTIVE DISORDER; LANGUAGE LATERALIZATION; GEOMETRICALLY ACCURATE; METAANALYSIS; VOLUMES; SEGMENTATION; SYMPTOMS; MRI;
D O I
10.1016/j.pscychresns.2024.111863
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Schizophrenia spectrum disorders (SSD) are debilitating, with auditory verbal hallucinations (AVHs) being a core characteristic. While gray matter volume (GMV) reductions are commonly replicated in SSD populations, the neural basis of AVHs remains unclear. Using previously published data, this study comprises two main analyses, one of GMV dissimilarities between SSD and healthy controls (HC), and one of GMV differences specifically associated with AVHs. Structural brain images from 71 adults with (n = 46) and without (n = 25) SSD were employed. Group differences in GMVs of the cortex, anterior cingulate (ACC), superior temporal gyrus (STG), hippocampi, and thalami were assessed. Additionally, volumes of left Heschl's gyrus (HG) in a subgroup experiencing AVHs (AVH+, n = 23) were compared with those of patients who did not (AVH-, n = 23). SSD patients displayed reduced GMVs of the cortex, ACC, STG, hippocampi, and thalami compared to HC. AVH+ had significantly reduced left HG volume when compared to AVH-. Finally, a right-lateralized ventral prefrontal cluster was found to be uniquely associated with AVH severity. This study corroborates previous findings of GMV reductions in SSD cohorts. Chiefly, our secondary analysis suggests that AVHs are associated with language areas and their contralateral homologues.
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页数:9
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