The Mid-Term Effect of Preservative-Free Artificial Tears Containing Hyaluronic Acid on Dry Eye Incidence after Cataract Surgery: A Retrospective Cohort Study

被引:1
|
作者
Lee, Chia-Yi [1 ,2 ,3 ]
Yang, Shun-Fa [1 ,4 ]
Chen, Hung-Chi [5 ,6 ,7 ]
Lian, Ie-Bin [8 ]
Huang, Chin-Te [9 ,10 ]
Huang, Jing-Yang [4 ]
Chang, Chao-Kai [2 ,11 ]
机构
[1] Chung Shan Med Univ, Inst Med, Taichung 40201, Taiwan
[2] Nobel Eye Inst, Taipei 10041, Taiwan
[3] Jen Ai Hosp Dali Branch, Dept Ophthalmol, Taichung, Taiwan
[4] Chung Shan Med Univ Hosp, Dept Med Res, Taichung 40201, Taiwan
[5] Chang Gung Mem Hosp, Dept Ophthalmol, Linkou 33305, Taiwan
[6] Chang Gung Mem Hosp, Ctr Tissue Engn, Taoyuan 33305, Taiwan
[7] Chang Gung Univ, Dept Med, Coll Med, Taoyuan 33305, Taiwan
[8] Natl Changhua Univ Educ, Inst Stat & Informat Sci, Changhua 50007, Taiwan
[9] Chung Shan Med Univ Hosp, Dept Ophthalmol, Taichung 40201, Taiwan
[10] Chung Shan Med Univ, Sch Med, Dept Ophthalmol, Taichung 40201, Taiwan
[11] Da Yeh Univ, Dept Optometry, Chunghua 51591, Taiwan
关键词
hyaluronic acid; dry eye disease; cataract surgery; superficial keratitis; tear break-up time; OCULAR SURFACE; DISEASE; FILM; MANAGEMENT; SYMPTOMS; SIGNS;
D O I
10.3390/diagnostics14171848
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of this study is to survey the effectiveness of preservative-free artificial tears containing hyaluronic acid (HA) on post-cataract surgery dry eye disease (DED) prevention. A retrospective cohort study was performed, and patients that received cataract surgeries were divided into either an HA group or non-HA group depending on the artificial tear they used. A total of 37 and 74 eyes were enrolled into the HA and non-HA groups, respectively, after the selection. The primary outcomes are postoperative superficial keratitis and multiple (>3) DED symptoms. The generalized linear model was utilized to calculate the adjusted odds ratio (aOR) and 95% confidence interval (CI) of primary outcomes between the two groups. There were 10 and 2 episodes of superficial keratitis in the non-HA group and HA group, respectively, and the HA group demonstrated a significantly lower incidence of superficial keratitis (p < 0.001). Moreover, 13 and 5 patients developed multiple DED symptoms in the non-HA and HA groups, and the HA group illustrated fewer multiple DED symptoms (p = 0.024). The lower preoperative tear break-up time (TBUT) was correlated with superficial keratitis in the HA group (p = 0.043), while old age, low preoperative TBUT and ocular surface staining were associated with superficial keratitis in the non-HA group (all p < 0.05). Lower preoperative TBUT was correlated with multiple DED symptoms in the HA group (p = 0.020), while female sex, low preoperative TBUT and any DED symptoms were associated with multiple DED symptoms in the non-HA group (all p < 0.05). In conclusion, the usage of preservative-free artificial tears containing HA is associated with lower postoperative DED events.
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页数:11
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