Upregulation of CKS2 in immunosuppressive cells is associated with metastasis and poor prognosis in prostate cancer: a single-cell RNA-sequencing analysis

被引:0
|
作者
Liang, Xiaoxing an [1 ,2 ]
Huang, Renlun [1 ,2 ]
Ping, Xin ue
Deng, Wei [1 ,2 ]
Xiang, Son ao [1 ,2 ]
Wang, Zhichao [1 ,2 ]
Gao, Jiadong [1 ,2 ]
机构
[1] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China
[2] Guangdong Prov Hosp Chinese Med, Dept Urol, Dade Rd 111, Guangzhou 510000, Peoples R China
基金
中国国家自然科学基金;
关键词
CKS2; bone metastasis; prostate cancer (PCa); single-cell RNA-sequencing analysis (single-cell RNA-seq analysis);
D O I
10.21037/tcr-23-2100
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Metastasis worsens prostate cancer (PCa) prognosis, with the immunosuppressive microenvironment playing a key role in bone metastasis. This study aimed to investigate how an immunosuppressive environment promotes PCa metastasis and worsens prognosis of patients with PCa. Methods: Candidate oncogenes were identified through analysis of the Gene Expression Omnibus (GEO) database. A prognostic model was developed for the purpose of identifying target genes. A single-cell RNA sequencing data from GEO database was used to analyze the localization of target genes in the tumor microenvironment. A pan-cancer analysis was conducted to study the cancer-causing potential of target genes across different types of tumors. Results: Fifty-one genes were found to be differentially expressed in bone metastasis compared to non-metastatic PCa, with CKS2 identified as the most significant gene associated with poor prognosis. CKS2 was shown to be linked to an immunosuppressive microenvironment and osteoclastic bone metastases, as shown by its negative correlation with immune cell infiltration and osteoblast-related gene expression. Moreover, CKS2 was found in immunosuppressive cells and was linked to bone metastasis in PCa. It was also overexpressed in different types of tumors, making it as an oncogenic gene. Conclusions: This research offers a new perspective on the potential utility of CKS2 as a therapeutic target for the prevention of metastatic PCa.
引用
收藏
页码:3996 / 4009
页数:14
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