Secondary structure changes as the potential H2 sensing mechanism of group D [FeFe]-hydrogenases

被引：0
|
作者：
Voloshyn, Ivan [1 ]
Schumann, Conrad [2 ]
Cabotaje, Princess R. [2 ]
Zamader, Afridi [2 ,3 ]
Land, Henrik [2 ]
Senger, Moritz [1 ,2 ]
机构：
[1] Uppsala Univ, Dept Chem, BMC, Biochem, S-75120 Uppsala, Sweden
[2] Uppsala Univ, Dept Chem, Angstrom Lab Mol Biomimet, S-75120 Uppsala, Sweden
[3] Univ Paris Cite, CNRS, Lab Electrochim Mol LEM, F-75006 Paris, France
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 78期
基金：
瑞典研究理事会;
关键词：
H-CLUSTER;
D O I：
10.1039/d4cc03098b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[FeFe]-hydrogenases function as both H2 catalysts and sensors. While catalysis is well investigated, details regarding the H-2 sensing mechanism are limited. Here, we relate protein structure changes to H-2 sensing, similar to light-driven bio-sensors. Our results highlight how identical cofactors incorporated in alternative protein scaffolds serve different functions in nature.
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页码：10914 / 10917
页数：4
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