Chemical Composition of Achillea millefolium L. and Their Anti-Inflammatory Activity

被引：0

作者：

Huang, Xinge ^{[1
,2
]}

Xu, Nannan ^{[1
]}

Liu, Zhitao ^{[1
,2
]}

Li, Hongliang ^{[1
]}

Lu, Hui ^{[1
,2
]}

Li, Jun ^{[1
,2
]}

机构：

[1] Xinjiang Tech Inst Phys & Chem, Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plants, Key Lab Plants Resources & Chem Arid Zone, South Beijing Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 08期

关键词：

Achillea millefolium; Chemical composition; C-13 NMR calculations with DP4+probability analyses; ECD calculations; Anti-inflammatory;

D O I：

10.1002/cbdv.202400946

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new monoterpene, (-)-10-hydroxydihydroactinidiolide (1), along with two known monoterpenes, loliolide (2) and (+)-isololiolide (3), three known megastigmanes, 3 alpha-hydroxy-5 beta,6 beta-epoxy-beta-ionone (4), 3 alpha-hydroxy-5 alpha,6 alpha-epoxy-beta-ionone (5), and (+)-dehydrovomifoliol (6), a eudesmane-type sesquiterpene, 4 alpha-hydroxy-4 beta-methyldihydrocostol (7), a monoterpene, 8-hydroxycarvotanacetone (8), two flavonoids, chrysoeriol (9) and apigenin (10), and a phenylpropanoid, 3-(4-hydroxyphenyl)-1-propanol (11), were isolated from the whole plant of Achillea millefolium. The structure of compound 1 was identified according to spectroscopic data of HRMS and NMR, and its absolute configuration was assigned by 13C NMR calculations with DP4+ probability analyses and ECD calculations. The absolute configuration of compound 6 was determined by ECD calculations. Compounds 3, 6, 9 and 10 could dose-dependently inhibit the NO release in LPS-induced RAW264.7 cells. image

引用

页数：5

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