An alternative and scalable synthesis for Relugolix

被引：0

作者：

Wang, Xuan ^{[1
]}

Luo, Ying ^{[1
]}

Zhang, Peng ^{[1
]}

Zhu, Xueyan ^{[1
]}

Liu, Xiangkui ^{[1
]}

Chen, Yinbo ^{[1
]}

机构：

[1] Shanghai Inst Pharmaceut Ind Co Ltd, China State Inst Pharmaceut Ind Co Ltd, 285 Gebaini Rd, Shanghai 201203, Peoples R China

来源：

TETRAHEDRON | 2024年 / 167卷

关键词：

Relugolix; New synthetic route; Optimization; Scale up;

D O I：

10.1016/j.tet.2024.134243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alternative and efficient synthetic route for Relugolix was accomplished by changing the construction order of three main parts A, B and C. After the optimization, its scale-up of the preparation for Relogulix was completed in a seven-step methodology with overall yield of 61 % and 99.62 % HPLC purity.

引用

页数：4

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