Gold-Catalyzed Heteroannulation of Anthranilic Acids with Alkynes: Synthesis of 3,1-Benzoxazin-4-ones

被引：1
|
作者：
Abe, Masahiro [1 ]
Takano, Mai [1 ]
Mizukami, Akiho [1 ]
Kimachi, Tetsutaro [1 ]
Inamoto, Kiyofumi [1 ]
机构：
[1] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 17期
关键词：
FUNCTIONALIZATION; INHIBITORS;
D O I：
10.1021/acs.joc.4c01602
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We demonstrated a rapid and facile approach for the synthesis of various 3,1-benzoxazin-4-ones via a gold-catalyzed heteroannulation of readily available nonprotected anthranilic acids and simple aryl alkynes. Our preliminary mechanistic investigation indicated that the double incorporation of alkynes into anthranilic acids occurs through the formation of bisenamine intermediates.
引用
收藏
页码：12651 / 12657
页数：7
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