Postoperative Acute Intracranial Hemorrhage and Venous Thromboembolism in Patients with Brain Metastases Receiving Acetylsalicylic Acid Perioperatively

被引:0
|
作者
Tonchev, Nikolay [1 ]
Pinchuk, Anatoli [1 ]
Dumitru, Claudia A. [1 ]
Neyazi, Belal [1 ]
Swiatek, Vanessa Magdalena [1 ]
Stein, Klaus Peter [1 ]
Sandalcioglu, Ibrahim Erol [1 ]
Rashidi, Ali [1 ]
机构
[1] Otto von Guericke Univ, Dept Neurosurg, Leipziger Str 44, D-39120 Magdeburg, Germany
关键词
ASA; metastases; craniotomy; hemorrhage; SINGLE-CENTER; PROPHYLAXIS; PREVENTION; MANAGEMENT; THROMBOSIS; CRANIOTOMY; RISK; NEUROSURGERY; ENOXAPARIN; SURGERY;
D O I
10.3390/curroncol31080343
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cranial operations are associated with a high risk of postoperative intracranial hemorrhage (pICH) and venous thromboembolic events, along with increased mortality and morbidity. With the use of acetylsalicylic acid (ASA) for prophylaxis becoming more prevalent, the risk of bleeding when ASA is administered preoperatively is unknown, as are the effects of discontinuation upon the occurrence of thromboembolic events, especially in societies with aging demographics. To address these questions, a retrospective analysis was performed using medical records and radiological images of 1862 patients subjected to brain tumor surgery over a decade in our department. The risk of pICH was compared in patients with metastases receiving ASA treatment versus patients not receiving ASA treatment. The occurrence of venous thromboembolic events after surgery was also evaluated. The study group consisted of 365 patients with different types of brain metastases. In total, 20 patients suffered pICH and 7 of these were associated with clinical neurological deterioration postoperatively. Of the 58 patients who took ASA preoperatively, 2 patients experienced pICH, compared with 5 patients in the non-ASA impact group (p = 0.120). Patients who took ASA were not at significantly higher risk of pICH and therefore a worse outcome compared to the group without ASA. Therefore, these data suggest that in patients at high cardiovascular risk, ASA can be safely continued during elective brain tumor surgery.
引用
收藏
页码:4599 / 4612
页数:14
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