Exploring TRIM proteins' role in antiviral defense against influenza A virus and respiratory coronaviruses

被引：1
|
作者：
Wei, Ying [1 ,2 ,3 ]
Song, Junzhu [1 ,2 ,3 ]
Zhang, Jingyu [1 ,2 ,3 ]
Chen, Songbiao [1 ,2 ,3 ]
Yu, Zuhua [1 ,2 ,3 ]
He, Lei [1 ,2 ,3 ]
Chen, Jian [1 ,2 ,3 ]
机构：
[1] Henan Univ Sci & Technol, Coll Anim Sci & Technol, Lab Funct Microbiol & Anim Hlth, Luoyang, Peoples R China
[2] Henan Univ Sci & Technol, Luoyang Key Lab Live Carrier Biomat & Anim Dis Pre, Luoyang, Peoples R China
[3] Henan Univ Sci & Technol, Key Lab Anim Dis & Publ Hlth, Luoyang, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2024年 / 14卷
基金：
中国国家自然科学基金;
关键词：
TRIM proteins; influenza A virus; respiratory coronavirus; viral components; innate immunity; FAMILY PROTEINS; RIG-I; TARGETS; IDENTIFICATION; RECOGNITION; TRIM5-ALPHA; INFECTION; IMMUNITY; SENSOR;
D O I：
10.3389/fcimb.2024.1420854
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Numerous tripartite motif (TRIM) proteins, identified as E3 ubiquitin ligases, participate in various viral infections through ubiquitylation, ISGylation, and SUMOylation processes. Respiratory viruses, particularly influenza A virus (IAV) and respiratory coronaviruses (CoVs), have severely threatened public health with high morbidity and mortality, causing incalculable losses. Research on the regulation of TRIM proteins in respiratory virus infections is crucial for disease prevention and control. This review introduces TRIM proteins, summarizes recent discoveries regarding their roles and molecular mechanisms in IAV and CoVs infections, discusses current research gaps, and explores potential future trends in this rapidly developing field. It aims to enhance understanding of virus-host interactions and inform the development of new molecularly targeted therapies.
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页数：8
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