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Acid-Mediated Intramolecular Cyclizations of (N-Aryl)-acetylenic Sulfonamides: Synthesis of Fused and Spirocyclic Sultams
被引:1
|作者:
Reddy, Chada Raji
[1
,2
]
Rathaur, Anjali
[1
,2
]
Sagar, Banoth Karuna
[1
,2
]
机构:
[1] CSIR Indian Inst Chem Technol IICT, Dept Organ Synth & Proc Chem, Hyderabad 500007, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源:
JOURNAL OF ORGANIC CHEMISTRY
|
2024年
/
89卷
/
19期
关键词:
2,1-BENZOTHIAZINE 2,2-DIOXIDE;
DERIVATIVES;
INHIBITORS;
SULFUR;
D O I:
10.1021/acs.joc.4c01517
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Herein, we report acid-mediated divergent annulations of (N-aryl)-alkynyl sulfonamides. The substituent at the para position of the N-aryl group determines two diverse reaction paths, leading to the selective assembly of benzo-fused sultams and spirocyclic sultams. This strategy provides a series of benzo/spiro-sultams with wide functional group compatibility and good to excellent yields under mild reaction conditions. Additionally, scale-up reaction and further transformations of the products were also carried out to demonstrate the utility of the protocol.
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页码:14120 / 14128
页数:9
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