Copper-promoted ortho-directed C-H amination of 2-arylpyridines with NH-heterocycles

被引：0
|
作者：
Zeng, Yang-Hao [1 ,2 ]
Dong, Lin [1 ,2 ]
机构：
[1] Sichuan Univ, Sichuan Engn Lab Plant Sourced Drug, Key Lab Drug Targeting & Drug Delivery Syst Educ M, West China Sch Pharm, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 36期
关键词：
AMIDATION; ARYLATION; PYRAZOLE; ARENES; BONDS; SITE;
D O I：
10.1039/d4ob01126k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-mediated C-N coupling of azaheterocycles with aryl C-H bonds has been realized for the synthesis of N-(hetero)arylated heteroarenes. This method is characterized by high regioselectivity, atom economy and a wide substrate scope of 2-arylazines and azaheterocycles. The corresponding C-N coupling products were shown to undergo further transformation to synthesize more complex molecules.
引用
收藏
页码：7390 / 7394
页数：5
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