Synovial microenvironment in temporomandibular joint osteoarthritis: crosstalk with chondrocytes and potential therapeutic targets

被引:0
|
作者
Wu, Zuping [1 ]
Wang, Ying [1 ]
Zhu, Mengqi [1 ]
Lu, Mingcheng [1 ]
Liu, Wei [1 ]
Shi, Jiejun [1 ]
机构
[1] Zhejiang Univ, Stomatol Hosp, Sch Stomatol, Key Lab Oral Biomed Res Zhejiang Prov,Canc Ctr,Eng, Hangzhou 310000, Peoples R China
基金
中国国家自然科学基金;
关键词
Chondrocytes; Synovial fibroblasts; Crosstalk; Temporomandibular joint osteoarthritis; MESENCHYMAL STEM-CELLS; CHONDROGENIC DIFFERENTIATION; INTERCELLULAR COMMUNICATION; CARTILAGE REGENERATION; EXTRACELLULAR VESICLES; FIBROBLASTS; PROGRESSION; EXOSOMES; CADHERIN-11; MATRIX;
D O I
10.1016/j.lfs.2024.122947
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Temporomandibular joint osteoarthritis (TMJOA) is considered to be a low-grade inflammatory disease involving multiple joint tissues. The crosstalk between synovium and cartilage plays an important role in TMJOA. Synovial cells are a group of heterogeneous cells and synovial microenvironment is mainly composed of synovial fibroblasts (SF) and synovial macrophages. In TMJOA, SF and synovial macrophages release a large number of inflammatory cytokines and extracellular vesicles and promote cartilage destruction. Cartilage wear particles stimulate SF proliferation and macrophages activation and exacerbate synovitis. In TMJOA, chondrocytes and synovial cells exhibit increased glycolytic activity and lactate secretion, leading to impaired chondrocyte matrix synthesis. Additionally, the synovium contains mesenchymal stem cells, which are the seed cells for cartilage repair in TMJOA. Co-culture of chondrocytes and synovial mesenchymal stem cells enhances the chondrogenic differentiation of stem cells. This review discusses the pathological changes of synovium in TMJOA, the means of crosstalk between synovium and cartilage, and their influence on each other. Based on the crosstalk between synovium and cartilage in TMJOA, we illustrate the treatment strategies for improving synovial microenvironment, including reducing cell adhesion, utilizing extracellular vesicles to deliver biomolecules, regulating cellular metabolism and targeting inflammatory cytokines.
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页数:13
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