Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review)

Tissue regeneration is a complex process that involves the recruitment of various types of cells for healing after injury; it is mediated by numerous precise interactions. However, the identification of effective targets for improving tissue regeneration remains a challenge. As an extracellular matrix protein, Agrin plays a critical role in neuromuscular junction formation. Furthermore, recent studies have revealed the role of Agrin in regulating tissue proliferation and regeneration, which contributes to the repair process of injured tissues. An in-depth understanding of the role of Agrin will therefore be of value. Given that repair and regeneration processes occur in various parts of the human body, the present systematic review focuses on the role of Agrin in typical tissue and highlights the potential signaling pathways that are involved in Agrin-induced repair and regeneration. This review offers important insight into novel strategies for the future clinical applications of Agrin-based therapies, which may represent a feasible treatment option for patients who require organ replacement or repair.