We investigated the effects of a single and simultaneous intake of allitol and D-allulose on body fat accumulation and cecal short-chain fatty acid (SCFA) production and accurately assessed the contribution of rare sugars to body fat in rats fed a high-fat diet that led to obesity. Thirty-two male 3-week-old Wistar rats were randomly divided into four groups: control, allitol, D-allulose, and allitol + D-allulose. The rats were fed experimental diets and water ad libitum for 11 weeks. High doses of allitol or D-allulose can induce diarrhea in rat; hence, each group of rats was acclimated to 1-5% allitol and D-allulose incrementally for the initial 20 days. After the feeding period, all rats were euthanized and collected tissues. Perirenal, mesenteric, and total intra-abdominal adipose tissue weights were significantly reduced by dietary Dallulose, whereas dietary allitol tended to decrease these adipose tissue weights. Both allitol and D-allulose significantly decreased carcass and total body fat mass. We confirmed that both dietary allitol and D-allulose inhibited body fat accumulation; however, D-allulose did not inhibit hepatic lipogenesis and no synergy was observed between dietary allitol and D-allulose in terms of anti-obesity effects. Dietary allitol significantly increased cecal SCFA levels and these effects were more potent than those of dietary D-allulose. The antiobesity effect of allitol may be due to the action of SCFAs, especially butyric acid, produced by the gut microbiota. Many of the effects of allitol as an alternative sweetener remain unknown, and further research is required.
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Hokkaido Bunkyo Univ, Fac Int Studies, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, JapanHokkaido Bunkyo Univ, Fac Int Studies, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
Higaki, Shunsuke
Inai, Reiko
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Nara Womens Univ, Dept Food Sci & Nutr, Kitauoyanishimachi, Nara, Nara 6308263, JapanHokkaido Bunkyo Univ, Fac Int Studies, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
Inai, Reiko
Mocinzum, Susumu
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Kagawa Univ, Fac Agr, 2393 Ikenobe, Miki, Kagawa 7610795, JapanHokkaido Bunkyo Univ, Fac Int Studies, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
Mocinzum, Susumu
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Yoshihara, Akihide
Ammitsp, Kazuya
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Kagawa Univ, Fac Agr, 2393 Ikenobe, Miki, Kagawa 7610795, JapanHokkaido Bunkyo Univ, Fac Int Studies, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
Ammitsp, Kazuya
Matspo, Tatsuhiro
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Kagawa Univ, Fac Agr, 2393 Ikenobe, Miki, Kagawa 7610795, JapanHokkaido Bunkyo Univ, Fac Int Studies, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
机构:
Hokkaido Bunkyo Univ, Fac Human Sci, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, JapanHokkaido Bunkyo Univ, Fac Human Sci, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
Higaki, Shunsuke
Inai, Reiko
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Univ Kochi, Fac Nutr, 2751-1 Ike, Ike, Kochi 7810111, JapanHokkaido Bunkyo Univ, Fac Human Sci, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
Inai, Reiko
Matsuo, Tatsuhiro
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Kagawa Univ, Fac Agr, 2393 Ikenobe, Miki, Kagawa 7610795, JapanHokkaido Bunkyo Univ, Fac Human Sci, 5-196-1 Koganechuo, Eniwa, Hokkaido 0611449, Japan
机构:
Department of Nutrition and Food Hygiene, School of Public Health, Southeast UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Lanlan Gui
Shaokang Wang
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Department of Nutrition and Food Hygiene, School of Public Health, Southeast UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Shaokang Wang
Jing Wang
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Nanjing Municipal Center for Disease Control and PreventionDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Jing Wang
Wang Liao
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Department of Nutrition and Food Hygiene, School of Public Health, Southeast UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Wang Liao
Zitong Chen
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Nanjing Municipal Center for Disease Control and PreventionDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Zitong Chen
Da Pan
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Department of Nutrition and Food Hygiene, School of Public Health, Southeast UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Da Pan
Hui Xia
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Department of Nutrition and Food Hygiene, School of Public Health, Southeast UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Hui Xia
Guiju Sun
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Department of Nutrition and Food Hygiene, School of Public Health, Southeast UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University
Guiju Sun
Su Tian
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Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University