Slowly Expanding Lesions Differentiate Pediatric Multiple Sclerosis from Myelin Oligodendrocyte Glycoprotein Antibody Disease

被引：0

作者：

Fadda, Giulia ^{[1
]}

Banwell, Brenda ^{[2
]}

Elliott, Colm ^{[3
]}

Fetco, Dumitru ^{[3
,4
,5
]}

Arnold, Douglas L. ^{[3
,4
,5
]}

Waters, Patrick ^{[6
]}

Yeh, E. Ann ^{[7
]}

Marrie, Ruth Ann ^{[8
]}

Bar-Or, Amit ^{[9
,10
]}

Narayanan, Sridar ^{[3
,4
,5
]}

机构：

[1] Univ Ottawa, Ottawa Hosp Res Inst, Dept Med, Ottawa, ON, Canada

[2] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Neurol, Philadelphia, PA USA

[3] NeuroRx Res, Montreal, PQ, Canada

[4] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[5] McGill Univ, Montreal Neurol Inst & Hosp, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[6] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England

[7] Univ Toronto, Dept Pediat, Toronto, ON, Canada

[8] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Community Hlth Sci, Winnipeg, MB, Canada

[9] Univ Penn, Ctr Neuroinflammat & Neurotherapeut, Philadelphia, PA USA

[10] Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA USA

来源：

ANNALS OF NEUROLOGY | 2024年 / 96卷 / 06期

基金：

加拿大健康研究院;

关键词：

BRAIN;

D O I：

10.1002/ana.27066

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Slowly expanding lesions (SELs) in adults with multiple sclerosis (MS) indicate a progressive pathological process. Whether SELs are present in pediatric-onset MS (POMS) or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unknown. We studied 19 children with POMS and 14 with MOGAD (median age 14.3 and 9.4 years, respectively) recruited to the Canadian Pediatric Demyelinating Disease Study with: (1) >= 3 research scans 12 months apart; and (2) >= 1 T2-lesions on the earliest scan. A total of 70 SELs from 16 POMS participants and 1 SEL in the MOGAD group were detected. SELs are an early feature of POMS and essentially not a feature of MOGAD. ANN NEUROL 2024

引用

页码：1086 / 1091

页数：6

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