HKUST-1 Derived Cu2S-Cu3P@C Nanomatrix Electrode Material for Non-Enzymatic Electrochemical Glucose Sensing

Robust Cu2S-Cu3P@C Nanomatrix electrode material has been synthesized via a two-step process involving carbonization of Cu-MOF, HKUST-1, followed by simultaneous phosphorization and sulphurization of the carbonized product. This seamless approach leads to the efficient incorporation of highly active Cu2S-Cu3P hybrid nanostructures within a conductive carbon matrix, exhibiting exceptional electrochemical glucose sensing performance. Synergistic interactions between Cu2S-Cu3P and the carbon matrix boost glucose electro-oxidation kinetics. The resulting Cu2S-Cu3P@C displays a broad linear response (0.005-5 mM), low detection limit (2.3 mu M), and high sensitivity (10,790 mu A mM(-1) cm(-2)), with excellent selectivity towards glucose even in the presence of interferents. This biomimetic Cu2S-Cu3P@C nanomatrix catalyst holds promise for biosensor development in bioanalysis and clinical diagnosis.