Metabolic Syndrome in Patients with Chronic Kidney Disease

Chronic kidney disease (CKD), the leading cause of end-stage renal disease, is associated with several metabolic derangements. Considering insulin resistance, evidence has shown higher prevalence of metabolic syndrome (MeS) in CKD. The aim of this study was to investigate association between the CKD and MeS. In this cross-sectional study, 450 individuals were included. Required clinical and laboratory data were recorded in questionnaires. MeS and CKD were defined according to NHLBI/AHA and KDIGO 2022 guidelines respectively. Increasing or decreasing trend for MeS among the means across quartiles of glomerular filtration rate was determined. Two-hundred twenty women and 230 men with mean age of 46.6 years were entered in this study. Patients with CKD were younger (42 years old versus 52, P < 0.001) and more active (1459.5 metabolic equivalence/min/week versus 1113.0). There was an increase in trend for MeS with decreasing GFR (P-Trend = 0.002), which remained significant after adjustment for age, sex, BMI, HOMA-IR, and physical activity (P-Trend = 0.049). MeS is more prevalent in patients with CKD which can additionally affect their general health.