Role of circRNAs in regulating cell death in cancer: a comprehensive review

被引:0
|
作者
Saadh, Mohamed J. [1 ]
Ehymayed, Hadi Mohammed [2 ]
Alazzawi, Tuqa S. [3 ]
Fahdil, Ali A. [4 ]
Athab, Zainab H. [5 ]
Yarmukhamedov, Bekhzod [6 ,7 ]
Al-Anbari, Hayder Hamid Abbas [8 ]
Shallal, Mohammed Mohsin [9 ]
Alsaikhan, Fahad [10 ,11 ]
Farhood, Bagher [12 ]
机构
[1] Middle East Univ, Fac Pharm, Amman 11831, Jordan
[2] Al Noor Univ Coll, Dept Med Lab Tech, Nineveh, Iraq
[3] Natl Univ Sci & Technol, Coll dentist, Dhi Qar, Iraq
[4] Al Farahidi Univ, Med Tech Coll, Baghdad, Iraq
[5] Al Zahrawi Univ Coll, Dept Pharm, Karbala, Iraq
[6] Tashkent State Dent Inst, Dept Oral Surg & Dent Implantol, Tashkent, Uzbekistan
[7] Samarkand State Med Univ, Dept Sci affairs, Samarkand, Uzbekistan
[8] Ahl Al Bayt Univ, Coll Pharm, Kerbala, Iraq
[9] Gilgamesh Ahliya Univ, Baghdad, Iraq
[10] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Alkharj, Saudi Arabia
[11] Ibn Sina Natl Coll Med Studies, Sch Pharm, Jeddah, Saudi Arabia
[12] Kashan Univ Med Sci, Fac Paramed Sci, Dept Med Phys & Radiol, Kashan, Iran
关键词
Cancer; Circular RNAs; Apoptosis; Autophagy; Ferroptosis; COMPETING ENDOGENOUS RNA; CIRCULAR RNA; BREAST-CANCER; LUNG-CANCER; GASTRIC-CANCER; OVARIAN-CANCER; PACLITAXEL RESISTANCE; INHIBITS APOPTOSIS; COLORECTAL-CANCER; CERVICAL-CANCER;
D O I
10.1007/s12013-024-01492-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Despite multiple diagnostic and therapeutic advances, including surgery, radiation therapy, and chemotherapy, cancer preserved its spot as a global health concern. Prompt cancer diagnosis, treatment, and prognosis depend on the discovery of new biomarkers and therapeutic strategies. Circular RNAs (circRNAs) are considered as a stable, conserved, abundant, and varied group of RNA molecules that perform multiple roles such as gene regulation. There is evidence that circRNAs interact with RNA-binding proteins, especially capturing miRNAs. An extensive amount of research has presented the substantial contribution of circRNAs in various types of cancer. To fully understand the linkage between circRNAs and cancer growth as a consequence of various cell death processes, including autophagy, ferroptosis, and apoptosis, more research is necessary. The expression of circRNAs could be controlled to limit the occurrence and growth of cancer, providing a more encouraging method of cancer treatment. Consequently, it is critical to understand how circRNAs affect various forms of cancer cell death and evaluate whether circRNAs could be used as targets to induce tumor death and increase the efficacy of chemotherapy. The current study aims to review and comprehend the effects that circular RNAs exert on cell apoptosis, autophagy, and ferroptosis in cancer to investigate potential cancer treatment targets.
引用
收藏
页码:109 / 133
页数:25
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