High-grade serous Ovarian Cancer: TP53 Mutations and Platinum Response

被引：0
|
作者：
Lorenz, Judith
机构：
来源：
GEBURTSHILFE UND FRAUENHEILKUNDE | 2024年 / 84卷 / 07期
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D O I：
10.1055/a-2308-6206
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Up to 96% of High-grade serous Ovarian Cancers have Mutations of the Tumor Suppressor Gene TP53. This results in a Loss of Function or Dysfunction of the Protein p53, which plays an important Role in Regulating the Cell Cycle. A US Research Team has now investigated the oncogenic Potential of various TP53 Mutations with regard to clinical Treatment Outcomes and in particular the Development of Platinum Resistance.
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